Abstract
Skin moisturizing has drawn attention in terms of beauty and anti-aging industries. However, it is difficult to observe the inside of the epidermis and the relationship between the epidermis and water content is not yet clear. Computational simulations can be useful in understanding such mechanisms of skin formation. A particle model was used to simulate three-dimensional skin turnover, and the results reproduced the epidermal skin turnover phenomenon. In this study, a diffusion model is introduced into this simulation model and a moisture diffusion analysis of the epidermis was performed. In particular, transepidermal water loss (TEWL) was modeled by considering diffusion and surface evaporation in the stratum corneum and other layers. The relationship between the moisture content and the keratin detachment was considered, and the exfoliation condition of keratin based on the moisture content was calculated in the model. As a result, it was possible to calculate the intraepidermal water content distribution in the skin using the particle model. It was also possible to reproduce phenomena such as keratin thickening due to increase of TEWL. This phenomenon is consistent with cases of dry skin. In the future, it will be necessary to introduce a change in TEWL according to the thickness of the stratum corneum and the diffusion coefficient.
Highlights
It was possible to reproduce phenomena such as keratin thickening due to increase of transepidermal water loss (TEWL). This phenomenon is consistent with cases of dry skin
It will be necessary to introduce a change in TEWL according to the thickness of the stratum corneum and the diffusion coefficient
TEWL was considered in the diffusion coefficient, and surface evaporation was considered in the stratum corneum and other layers
Summary
Skin moisturizing is closely related to the moisture content of the entire epider-. We proposed a particle model that can handle complex biological phenomena, including cell interactions such as cell division, motion, deformation, and transition [5] [6]. This model was applied to the formation and turnover process of skin [7]. TEWL (transepidermal water loss) was considered in the diffusion coefficient, and surface evaporation was considered in the stratum corneum and other layers. The model can simulate the intraepidermal water content distribution and the structure in the skin
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