Abstract
The 3D NiO hollow sphere/reduced graphene oxide (rGO) composite was synthesized according to the coordinating etching and precipitating process by using Cu2O nanosphere/graphene oxide (GO) composite as template. The morphology, structure, and composition of the materials were characterized by SEM, TEM, HRTEM, XPS, and Raman spectra, and the electrochemical properties were studied by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and amperometry. Moreover, the electrochemical activity of the composite materials with different morphologies were also investigated, which indicating a better combination of the NiO hollow sphere and the rGO. Used as glucose sensing material, the 3D NiO hollow sphere/rGO composite modified electrode exhibits high sensitivity of ~2.04 mA mM−1 cm−2, quick response time of less than 5 s, good stability, selectivity, and reproducibility. Its application for the detection of glucose in human blood serum sample shows acceptable recovery and R.S.D. values. The outstanding glucose sensing performance should be attributed to the unique 3D hierarchical porous superstructure of the composite, especially for its enhanced electron-transfer kinetic properties.
Highlights
Electrochemical biosensors have been extensively applied to detect biological substances via catalysis and recognition behaviors happening on the surface of electrodes in the fields of medicine, food, industry and environment[1,2,3,4]
The pre-preparation of the Cu2O/graphene oxide (GO) composite template is very important for the successful preparation of the 3D NiO hollow sphere/rGO composite
3D Ni(OH)[2] hollow sphere/GO composite was rapidly obtained by selecting S2O32− as the etchant towards the 3D Cu2O/GO composite according to the “coordinating etching and precipitating” (CEP)” process
Summary
Electrochemical biosensors have been extensively applied to detect biological substances via catalysis and recognition behaviors happening on the surface of electrodes in the fields of medicine, food, industry and environment[1,2,3,4]. The effective application of metal oxides is prospective to break through the pivotal limitations of the costly enzymes since the typical glucose oxidase is intrinsically susceptible to the physical and chemical environments[1, 12,13,14]. Nanostructured metal oxides, such as zero–dimensional (0D) particles, 1D nanowires, 2D nanosheets, and some hollow structures have been widely studied as electrode materials for glucose biosensors with improved sensitivity, reproducibility, and stability. The outstanding glucose-sensing properties are attributed to its unique 3D porous structure, which facilitates superior electrocatalytic activity and remarkable electron-transfer kinetics
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
