Abstract
In aqueous media, biologically active substances are usually unstable, poorly soluble compounds with low bioavailability. Incorporation of these compounds into the structure of lipid-based lyotropic liquid crystalline phase or nanoparticles can increase their solubility and subsequent bioavailability. The aim of this review is to clarify the principle of self-assembly of lipidic amphiphilic molecules in the aqueous environment, to present lipid bicontinuous cubic and hexagonal phases and their current biological application.
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