Abstract
Tissue regeneration is probably the most ambitious aim for the tissue engineering research field. Even more difficult it becomes when we attempt to regenerate a complex organ that we do not fully understand, such as the brain. That is why in recent years we have observed an increased number of approaches that strive to create functional brain or networks in vitro in order to study their properties and develop platforms that can be used for biomedical applications. In this review, we will describe how, among all, carbon-based materials took over all the other materials as the most interesting and promising not only in the electronic industry but also to create 3D functional models of the brain in vitro.
Highlights
Understanding the interaction between nanomaterials and biosystems has become crucial in recent years
One recent study observed excitatory axons growing in reduced graphene oxide (rGO) foams through the injury site by functional blood microvessels, implying that these scaffolds improved the neuronal recovery after spinal cord injury [41]
These findings demonstrated that rGO could be useful for neuronal regeneration
Summary
Understanding the interaction between nanomaterials and biosystems has become crucial in recent years. Ulloa Severino and collaborators for the first time were able to culture primary rat hippocampal cells on the 3D-GFs and demonstrated that, using calcium imaging techniques and theoretical models, in 3D there are different neural networks properties [26].
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