Abstract
Interactions between nuclear envelope (NE) and lamina-associated domains (LADs), as well as interactions between topologically associating domains (TADs), are expected to shape various aspects of 3D chromatin structure and dynamics at the level of the entire nucleus. However, relevant genome-wide experiments that may provide statistically significant conclusions remain difficult. We have developed a dynamic coarse-grained model of the Drosophila melanogaster nucleus at TAD (∼100 kb) resolution that explicitly accounts for four distinct epigenetic classes of TADs and describes a time evolution of all chromosomes over the entire interphase.
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