393 Recurrent short interpregnancy interval: maternal and neonatal consequences

Abstract

To evaluate maternal and neonatal outcomes associated with recurrent short interpregnancy interval (IPI) in women in their third delivery. A retrospective computerized data base study of all women who delivered their first three consecutive deliveries in a single medical center over a 20-year period (1999-2019). Maternal and neonatal of women with recurrent short IPI (<6 months) were compared to women with recurrent normal IPI (18-48 months). Comparison analysis was performed by univariate analysis and followed by adjusted multiple logistic regression models (adjusted OR [aOR] (95% Confidence Interval [CI]). During the study period 252,199 deliveries of 109,457 women occurred at the Shaare Zedek Medical Center, of which we identified 10,569 (9.7%) women who underwent all their first three consecutive deliveries and met the inclusion criteria. Out of those, 338 (0.3%) women in their third delivery had two previous consecutive IPI of less than 6 months (recurrent short IPI) and 1,021 (0.9%) women had two IPI of between 18 to 48 months (recurrent normal IPI). Women in their third delivery with recurrent short IPI had signficant higher rates of maternal anemia (Hb<10gr%) at admission (7.4% vs 4.2%, p value = 0.02) and higher rates of small for gestational age neonates (8% vs. 5% p value = 0.04), as compared with women with recurrent normal IPI. The multivariate models revealed that recurrent short IPI was found to be independently associated with maternal anemia (Hb<10gr%) with aOR of 3.4 (1.09-10.65) and SGA - 9.4 (2.19-40.32). Recurrent short IPI is associated with anemia and small for gestational age. Consideration and awareness should be given for the iron deficiency and antenatal fetal weight follow up during pregnancy.View Large Image Figure ViewerDownload Hi-res image Download (PPT)