Abstract
Most immunodeficiencies affect phagocytes as well as lymphocytes, reflecting their shared hematopoietic origin. However, several are regarded as primarily phagocytic, largely reflecting not only their major manifestations and infections but also the state of knowledge when they were identified and named. Phagocyte immunodeficiencies are those that affect the number or function of phagocytes, reflected primarily in their associated infections. Infections most typical of phagocyte defects are caused by bacteria and fungi, which are typically invasive and severe. One of the hallmarks of phagocyte immune deficiencies is that they sum the effects of both infection susceptibility and immune dysregulation, reflecting the dual nature of phagocytic cells in both controlling local invaders and in regulating and “mopping up” the havoc that those invaders cause. This complex mixture of too little infection prevention and too little inflammation regulation makes the phagocyte immunodeficiencies complex to manage clinically.
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