Abstract
Psoriasis is a common chronic inflammatory skin disease characterized by a vicious circle of inflammation in the skin as a result of aberrant keratinocyte-immune cell communication. microRNAs (miRNAs) are short non-protein coding RNAs that can repress up to hundreds of target genes. We and others have previously shown the involvement of miRNAs in the pathogenesis of psoriasis. Recently we identified miRNAs differentially expressed in psoriasis keratinocytes, by small RNA sequencing of CD45neg epidermal cells from psoriasis lesional and non-lesional skin and healthy skin.
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