Abstract

The HERACLES-A trial demonstrated trastuzumab and lapatinib (T+L) activity in HER2-amplified (HER2+) KRAS exon 2 wild-type metastatic colorectal cancer (mCRC). We conducted the HERACLES RESCUE trial to test whether therapeutic sequencing with another anti-HER2 regimen at progression to T+L is active in these patients.

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