Abstract
Mesenchymal stem cell-based therapies are emerging as promising approach to promote cutaneous regeneration of chronic wounds. We assessed here the regenerative potential of a patch concentrating mesenchymal stem cells extracted from the human fat, i.e. adipose-derived stem cells (ASC), in a gelatin matrix. ASC cultures were derived from the subcutaneous abdominal fat of four patients. Principal component analysis on microarray data revealed that ASC grown within the patch upregulate the transcription of genes important for wound healing, including VEGF, CXCL12 and FGF7.
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