Abstract
Fibroblast growth factor (FGFR) alterations are implicated across a range of solid tumors, promoting oncogenesis as a result of amplification, mutations, and structural variations. The FGFR gene family consists of four highly conserved transmembrane tyrosine kinase receptors (FGFR1–4). FGFR signaling influences angiogenesis and tumor cell migration, differentiation, proliferation, and survival. Recently, the cIMPACT-NOW released update 4 and update research, which considered FGFR alterations as a marker in brain tumor classification and prognosis.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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