Abstract
Brain HMAO SPECT studies are used to evaluate brain activity in clinical populations. SPECT studies are also conducted in protocols comparing the brain’s resting state with that seen during an activation procedure. However, no data are available to evaluate the stability of these measures over time. We conducted HMPAO-SPECT studies of 6 normal control subjects (3 males age 32 ± 6.5 years and 3 females age 31 ± 14.5 years) on two occasions at least one week apart. Conditions of each study were maintained constant. To minimize the effects of ambient sound and light, subjects were injected while reclining in a relaxed mode in a sound-attenuating booth with eyes covered. To reduce anxiety, the HMPAO was injected via a previously-prepared I.V. line which passed out of the booth. The SPECT images were obtained by triple-headed gamma camera one-hour post-injection of the standard dose of 25 mCi of Tc-99m HMPAO. The analysis of images involved coregistration in space and intensity normalization. Two methods of analysis were used. One, involved the analysis of regions of interest identified by MRI. Method two involved voxel-by-voxel evaluation based on Statistical Parametric Mapping (SPM). The results of these analyses showed that there were no significant differences between the two studies. The range of differences in the ROI analysis was 1–2.5%. The SPM analysis resulted in no detectable difference at the level of p < 0.05. These data provide evidence that brain perfusion studies by HMPAO SPECT under well-controlled conditions are a stable and useful tool for the evaluation of brain function over time.
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