Abstract
Purpose: Cardiopulmonary exercise test (CPET) has been the most accurate method to assess the aerobic capacity among heart failure (HF) patients and is also of great value to estimate prognosis and detect candidates for heart transplantation. We studied the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and aerobic capacity in heart failure patients. Methods: We retrospectively analyzed data from 123 patients with definite diagnoses of heart failure between December 2012 and August 2015. All of them had performed the symptom limited maximal CPET to calculate the maximum oxygen consumption (PeakVO2). Blood samples had been taken within 24 hours to test NT-proBNP plasma levels, which is used to estimate Peak VO2 among these patients. Results: Plasma levels of NT-proBNP correlates significantly with Peak VO2 among the HF patients(r= -0.342, P 1176pg/ml showed 64% sensitivity and 76% specificity for estimating Peak VO2 1817 pg/ ml showed 80% sensitivity and 71% specificity for estimating Peak VO2 1176pg/ml was to predict Peak VO2 1817 pg/ml was to predict Peak VO2< 10 ml/kg/min (OR= 9.93, 95%CI 2.61-37.79). Conclusion: NT-proBNP could reflect aerobic capacity in HF patients. More HF patients who were potential heart transplant recipients should perform CPET especially when plasma levels of NT-proBNP were above 1800pg/ml.
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