Abstract
Recent studies have demonstrated that suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor, reduces experimental acute graft-versus-host disease (GVHD). We investigated the cellular-molecular mechanisms of immuno-modulation by two HDAC inhibitors, SAHA and ITF 2357. Stimulation of bone marrow derived dendritic cells (DCs) with various TLR ligands (lipopolysaccharide (LPS), PGN, CpG) after pretreatment with either SAHA caused a significant reduction in the secretion of TNF-α, IL-12p70 and IL-6 compared to the untreated controls (P< 0.01).
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