Abstract
Propofol may have clinically significant advantages compared with conventional sedative-hypnotic agents when used for prolonged or advanced therapeutic endoscopic procedures, but therapeutic endoscopy under propofol monosedation is not risk-free. In clinical practice, propofol is commonly administered in combination with low doses of benzodiazepine and/or analgesics. However, there are few controlled studies that assess the efficacy and safety of combination therapy consisting of propofol, benzodiazepine, and analgesics in therapeutic endoscopy.
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