Abstract

Background: We conducted a translational study on enrolled patients in a phase I/II trial of anti PD-L1 durvalumab (Du) combined with cetuximab (Ctx) and radiotherapy (RT) in locally advanced squamous cell carcinoma of the head and neck (DUCRO trial, NCT03051906). The aim was to evaluate the immunological profile and to investigate the dynamics of cytokine production in peripheral blood mononuclear cells (PBMCs).

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