Abstract
Psoriasis is an inflammatory disorder which leads to the improper stratification of epidermal keratinocytes. Autophagic flux analysis of our established cell lines has shown that autophagy is functionally active in healthy keratinocytes but is impaired in psoriatic keratinocytes. To mirror psoriasis in vitro we custom-made a cytokine cocktail that induced IL-1β release in keratinocyte cultures. Stimulation of healthy keratinocytes by this chronic inflammatory cocktail similarly causes autophagy block and accumulation of key autophagy proteins.
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