343 Quorum Quenching: A promising and physiological microbial control strategy

Abstract

Many pathogens rely on cell-to-cell communication mechanisms such as the Quorum Sensing system (QS) to synchronize microbial activities essential for infection and survival in the host. In the skin, Pseudomonas aeruginosa (Pae) and Staphylococcus aureus (Sa) respectively secrete autoinducers and cyclic autoinducing peptides to promote their virulence. However, on the top of increasing bacterial motility and spreading, these molecules also disturb the skin barrier. Quenching microbial Quorum Sensing or in short, Quorum Quenching suggests a promising and physiological microbial control strategy in certain skin dysbiosis.