Abstract
We have previously shown that ischemia and reperfusion injury (I/R) in the forepaw muscles of adult Swiss Webster mice decreased mechanical thresholds and increased firing to chemical stimuli in group III and IV muscle afferents as assessed by an ex vivo forepaw muscle-median and ulnar nerve-DRG-spinal cord recording preparation. Additionally, I/R induced a significant increase in the number of cells that responded to both non-noxious (low lactic acid and ATP concentrations; pH 7.0) and noxious (high lactic acid and ATP concentrations, pH 6.6) metabolite solutions.
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