#340 : Autologous Platelet-Rich Plasma (PRP) Treatment for Thin Endometrium in Yasmin IVF Clinic RSCM

Abstract

Background and Aims: PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. PRP is one of the trends in regenerative medicine and also being used in reproductive medicine area, one of which is to treat thin endometrial problems by infused intrauterine. The goal of this treatment is to reach suitable endometrial thickness by enhancing proliferation of endometrial cells. A good and receptive endometrium is necessary to achieve successful embryo implantation, both in natural pregnancy and assisted reproductive technology. This study aimed to analyze the outcome of PRP treatment during 2022 in Yasmin IVF Clinic RSCM. Method: This is a retrospective study which collected PRP service data during 2022 in Yasmin IVF Clinic RSCM. 76 subjects underwent PRP intrauterine infusion with thin endometrium indication ([Formula: see text]6 mm). Subjects were then categorized into two groups, first only underwent PRP procedure once and another group underwent intrauterine PRP procedure two times. Subjects underwent intrauterine PRP procedure more than two times were excluded from this study. All data were then statistically analyzed. Results: 76 subjects underwent intrauterine PRP infusion in Yasmin IVF Clinic RSCM during 2022. All subjects were diagnosed with thin endometrium ([Formula: see text]6 mm). Only 23 subjects underwent one intrauterine PRP procedure based on endometrial thickness assessment. The rest of the subjects, 53 patients underwent intrauterine PRP infusion two times. After PRP infusion, the endometrium thickness in PRP group was 8.37 ±0.22 mm, which was significantly thicker than that in control group (6.05 ±0.23 mm) (P [Formula: see text]0.05). However, implantation rate and clinical pregnancy rate in PRP group were not significantly higher than those in control group (28% vs 9%; 37% vs 20%; P [Formula: see text]0.05; respectively). Conclusion: Intrauterine PRP infusion seemed to be a good option in facing thin endometrium diagnosis. It is able to enhance endometrial thickness. However, the result of clinical pregnancy still needs to be improved.