Abstract
Epigenetics has become an increasingly important area of biomedical research. Accumulated evidence shows that epigenetic factors not only regulate stem cell differentiation, organism development, and multicellular function and behavior, but also affect common pathologic processes, including inflammation, ischemia, cancer, aging, and neurodegenerative diseases. Importantly, epigenetic mechanisms appear to play a critical role in the pathogenesis of complex retinal diseases, such as diabetic retinopathy, age-related macular degeneration, intraocular tumors, and retinitis pigmentosa. Understanding the role of epigenetic mechanisms in retinal diseases may provide new insights into complex eye diseases and contribute to the development of new therapies for the treatment of retinal diseases. This chapter summarizes the current knowledge of involvement of epigenetic factors in retinal development and disease.
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