Abstract
The Basel Familial Cancer Study Group concentrates on the family history for cancer control. Results of the first 1000 cancer patients interviewed: 29% have one, 10% two, 5% three or more first degree relatives with cancer. 9% have one or more first degree relatives with the same malignancy. DNA is stored and analyzed from members of conspicuous families. Germlike mutations are identified in colorectal and breast cancer families. Persons affected are entered into preventive pilot studies (endoscopy, sulindac, tamoxifen, psychosocial evaluation). The family history is becoming an important element in national early detection efforts of the Swiss Cancer League.
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