Abstract
Our objective was to prospectively validate a Point-of-Care (POC) hemoglobin device (Hemocue 201 DM system) as an alternative to a laboratory based complete blood count (CBC) in the setting of hemoglobin evaluation during cordocentesis and intrauterine fetal transfusion. This prospective study was performed in a tertiary level maternity hospital. Fifteen consecutive cases of fetal anemia attending the hospital for cordocentesis and intrauterine fetal transfusion over an 18 month period were included. At the time of cordocentesis all participants had at least two episodes of dual fetal blood sampling with both a POC Test and a laboratory-based CBC. Statistical analysis was performed via Pearson’s test. Fifteen cordocentesis procedures were performed during the 18 month period yielding a total of 35 paired samples. There was strong correlation between the POC hemoglobin and a CBC hemoglobin with r=0.976 (95% CI 0.952-0.988) and a p value <0.0001. This study demonstrated a linear fit between both methods of hemoglobin quantification enabling the prediction of the anticipated CBC hemoglobin from CBC hemoglobin via the equation Hemocue Hemoglobin = 2.902 + 0.9617 Laboratory Hemoglobin. Overall there is good agreement between the POC fetal hemoglobin and the CBC fetal hemoglobin. This suggests that the Hemocue 201 DM system is a viable and reproducible alternative form of measurement of fetal hemoglobin, with the important advantage of providing expedited results at the bedside. This ultimately may reduce fetal morbidity associated with cordocentesis and intrauterine transfusion, minimizing the time required to complete the procedure.View Large Image Figure ViewerDownload Hi-res image Download (PPT)
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