Abstract
Neonatal immunological challenge produces long-term neuroendocrine, immune and behavioural alterations. Our findings indicate that exposure to lipopolysaccharide (LPS; 0.05 mg/kg, i.p.) on postnatal days (PNDs) 3 and 5 impairs sexual behaviour in rats, most notably in the female. Here we investigated the effect of neonatal LPS on female reproductive development. Developmental weight gain, puberty onset and oestrous cyclicity were monitored. Circulating HPA/HPG hormones and ovarian morphology were examined throughout the development. Mating success and markers of reproductive development in the offspring were evaluated. Given the known involvement of the sympathetic nervous system in regulating ovarian maturation, tyrosine hydroxylase (TH) phosphorylation was assessed in neonatal adrenals. LPS exposure increased TH phosphorylation in neonatal adrenals ( p p p p p p p p p p
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