Abstract
G A A b st ra ct s increased median number of UC flares during the last 5 years of follow-up (5.5 vs. 1.5 years, P=0.02). The type of biliary involvement (intrahepatic, extrahepatic, or both) was similar in both groups. (Table 1) Kaplan-Meier curve analysis suggested that patients with elevated IgG4 had shorter colectomy-free survival than patients with normal IgG4. (Log Rank p<0.001) (Figure 1) However the time to OLT and the overall survival was no different. None of the patients had associated autoimmune pancreatitis. Conclusions: Elevated IgG4 was seen in a small number of PSC patients. The majority of these patients had associated UC, were younger at the time of PSC diagnosis, more likely to have backwash ileitis and had reduced colectomy-free survival suggesting more severe colitis than patients with normal IgG4. Table 1. Comparison of Demographic and Clinical Variables between PSC Patients with or without elevated IgG4
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