Abstract
Introduction: Activation of vitamin D receptor (VDR) inhibits cell growth and promotes differentiation, important functions in preventing cancer development. These effects have been attributed to a host of novel vitamin D derivatives that require the presence of specific cytochrome P450 (CYP) enzymes for biosynthesis. However, knowledge of the expression of these enzymes at single-cell resolution is lacking, and it is unknown if the expression changes with aging. Such information is critical to translating novel vitamin D derivatives to the clinic.
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