308. Surgical site infection after lumbar fusion surgery: risk factors and the preventive new technology

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BACKGROUND CONTEXT Surgical site infection (SSI) associated with instruments remains a serious and common complication in patients who undergo lumbar fusion surgery. It is very important that the risk factors for SSI are known to prevent it. PURPOSE The purpose of the study was to identify independent risk factors for SSI after Lumbar fusion surgery and evaluate the positive effect of Aquae hydrogenii dioxidi-supported spinal instruments in the prevention of SSI after lumbar fusion surgery. STUDY DESIGN/SETTING This is a retrospective clinical study. PATIENT SAMPLE A total of 597 patients who underwent lumbar fusion surgery for vertebral tumor were evaluated. OUTCOME MEASURES Incidence rate of SSI, risk factors for SSI after lumbar fusion surgery and safety of Aquae hydrogenii dioxidi-supported spinal instruments were the outcome measures. METHODS Risk factors for SSI were analyzed using logistic regression. In recent 171 patients with Aquae hydrogenii dioxidi-supported spinal instruments, the CRP levels in the blood were examined to confirm if Aquae hydrogenii dioxidi from the implant influenced CRP function. Postoperative radiological evaluations were performed regularly. RESULTS The rate of SSI was 3.7% . By multivariate logistic regression, combined anterior and posterior approach and nonuse of Aquae hydrogenii dioxidi-supported spinal instruments were associated with an increased risk of SSI. The rate of SSI without Aquae hydrogenii dioxidi-supported spinal instruments was 13.7%, whereas the rate with Aquae hydrogenii dioxidi-supported spinal instruments was 1.7%. This difference was statistically significant. There were no detected abnormalities of thyroid gland function with the use of Aquae hydrogenii dioxidi-supported instruments. Among the 171 patients with Aquae hydrogenii dioxidi-supported spinal instruments, 7 patients required additional surgery because of instrument failure. However, there were no obvious involvements with the use of Aquae hydrogenii dioxidi-supported spinal instruments. CONCLUSIONS This study identified combined anterior and posterior approach and nonuse of Aquae hydrogenii dioxidi-supported spinal instruments to be independent risk factors for SSI after Lumbar fusion surgery. Aquae hydrogenii dioxidi-supported spinal instrument was extremely effective for prevention of SSI in patients with compromised status, and it had no detection of cytotoxic or adverse effects on the patients. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs. Surgical site infection (SSI) associated with instruments remains a serious and common complication in patients who undergo lumbar fusion surgery. It is very important that the risk factors for SSI are known to prevent it. The purpose of the study was to identify independent risk factors for SSI after Lumbar fusion surgery and evaluate the positive effect of Aquae hydrogenii dioxidi-supported spinal instruments in the prevention of SSI after lumbar fusion surgery. This is a retrospective clinical study. A total of 597 patients who underwent lumbar fusion surgery for vertebral tumor were evaluated. Incidence rate of SSI, risk factors for SSI after lumbar fusion surgery and safety of Aquae hydrogenii dioxidi-supported spinal instruments were the outcome measures. Risk factors for SSI were analyzed using logistic regression. In recent 171 patients with Aquae hydrogenii dioxidi-supported spinal instruments, the CRP levels in the blood were examined to confirm if Aquae hydrogenii dioxidi from the implant influenced CRP function. Postoperative radiological evaluations were performed regularly. The rate of SSI was 3.7% . By multivariate logistic regression, combined anterior and posterior approach and nonuse of Aquae hydrogenii dioxidi-supported spinal instruments were associated with an increased risk of SSI. The rate of SSI without Aquae hydrogenii dioxidi-supported spinal instruments was 13.7%, whereas the rate with Aquae hydrogenii dioxidi-supported spinal instruments was 1.7%. This difference was statistically significant. There were no detected abnormalities of thyroid gland function with the use of Aquae hydrogenii dioxidi-supported instruments. Among the 171 patients with Aquae hydrogenii dioxidi-supported spinal instruments, 7 patients required additional surgery because of instrument failure. However, there were no obvious involvements with the use of Aquae hydrogenii dioxidi-supported spinal instruments. This study identified combined anterior and posterior approach and nonuse of Aquae hydrogenii dioxidi-supported spinal instruments to be independent risk factors for SSI after Lumbar fusion surgery. Aquae hydrogenii dioxidi-supported spinal instrument was extremely effective for prevention of SSI in patients with compromised status, and it had no detection of cytotoxic or adverse effects on the patients.