Abstract
Background: Hypoxic-ischemic (HI) injury induced by partial cord clamping produces brain damage. MgSO4 infusion has been used as a neuroprotector, but it produces haemodynamic and cardiac changes.Aim: To determine the effects of MgSO4 infusion on cerebral oxygenation, cardiovascular parameters and regional cerebral flow (RCBF) in preterm lambs with perinatal asphyxia induced by umbilical cord occlusion.Methods: 18 preterm lambs (80–90% GE) were used. Lambs were randomly assigned to receive magnesium sulphate (MGSO4) or not (SHAM) after HI injury induced by partial cord clamping. Non-injured group was used as (CONTROL). Carotid blood flow (CBF), systemic arterial pressure (SAP), heart rate (HR), arterial oxygen content (CaO2) and O2-uptake were measured. RCBF by microspheres and previous parameters were determined at fetal point (F), post-injury (P-I), 1h and at the end of the experiment. Frontal, parietal, temporal and occipital cortex were grouped (C), and striatum, thalamus, hypothalamus and hippocampus as periventicular zones (P). One factor ANOVA, p<0.05Results: After injury, H-I injured groups developed acidosis, hypoxia and hypercapnia in comparison with control group. Also, they demonstrated an increase in HR without change on SAP. MgSO4 infusion did not showed significant changes in SAP, HR, CBF and O2-uptake in comparison with other groups.Conclusion: In our model of perinatal asphyxia by partial occlusion of umbilical cord in premature foetal lambs, MgSO4 infusion does not compromise the cardiovascular adaptation to asphyxia. However, histopathological analysis of brain tissue and neuronal metabolic status must be study to evaluate the neuroprotective effect of MgSO4. Supported by grants: FIS 03/987 and RESPIRA net of RITC, FIS C03/11.
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