Abstract
During the fetal A there is an increase in heart, brain and adrenal blood flows together with a decrease in kidney, gut and carcass blood flows. Since the O2 to the fetal organs has not been determinated during a prolong A, we neasured the O2 during a 40 min reduction of the uteroplacental blood flow (UBF) to 50% of its basal value. In 5 sheep (0.8 - 0.9 of gestation) an infatable cocluder was plaoed around the uterine artery. Catheters were inserted in the fetal famoral vein and artery, carotid artery and jugular vein. Fetal organ blood flows (radiolabeled microspheres) and O2 content in ascending and descending aorta (Hamoximeter) were measured in basal condition and during a 50% reduction in UBF (+20 min and +40 min). Oxygen delivery to fetal organs was calculated: O2=organ blood flow × O2 content. Results were (X ± SEM; n=5 * =p < 0.05, ANOVA)These results show that during a prolonged fetal asphyxia O2 to the “Vital” is maintained at the expense of a reduction of O2 to the “non-vital” organs. The 75% reduction of O2 to the “non-vital” organs probably produces tissue hypoxia that could explain the damage observed in these organs during asphyxia. Grant 2183 – 8733, DIB, Universidad de Chile.
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