Abstract
In the last decades allergies are increasing in the western countries and different protein families were identified as determinants of allergenicity. In apple fruit, one of the most important fruit crop in the world, four allergen families (Mal d 1–4) have been identified so far, including pathogenesis-related proteins 10, thaumatin-like proteins, lipid transfer proteins and profilins. Moreover, it has been demonstrated that patient sensitivity differs in relation to apple variety, fruit tissue, cultivation and conservation conditions, increasing the difficulties to associate genetic, molecular and biochemical data with the results of clinical tests. Mapping studies and the availability of the complete apple genome sequence confirmed that allergens are organized in large families with many different isoforms, the contribution of which to allergenicity is still largely unknown. The unravelling of allergy determinants is crucial for different reasons:
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