2E22 赤血球サスペンション流れにおける血小板模擬粒子の流路内分布 : 円管と矩形管の違い

Abstract

In blood flow through microvessels, platelets have high concentrations near the vessel wall, which is referred to as "Near Wall Excess (NWE)" and plays an important role in restoration and hemostasis of injured vessel walls. In the present study, we measured the distributions of platelet sized fluorescent particles in red blood cell (RBC) suspensions flowing through microchannels with circular or square cross-sections and compared their results. The measurements were performed at various heights from the channel bottom, by the use of a confocal laser scanning microscope. In the absence of RBCs, the platelet-sized particles showed nearly uniform distributions in the channel cross-section for both of circular and square channels. In square channel flows with RBCs, higher concentrations of the particles were observed near the channel walls and this NWE was more conspicuous near the channel bottom than that in the mid-plane of the channel. This result suggests that the particles are accumulated near the corners in the square cross-section. In circular channel flows with RBCs, in contrast, the highest NWE was observed in the mid-plane. The extent of NWE was larger in circular channels than in square channels at comparable flow conditions.