2D→3D Polycatenated Cu(I) Coordination Polymer: Photocatalytic Property and Protective Activity on COPD by Reducing the INF-γ Production.

Jun-Fei Zhu,Jian Yang,Li-Tong Jin,Wei-Wei Yang

doi:10.1007/s10895-021-02850-w

Abstract

Reported here is a new [Cu4I4] cluster-based coordination polymer, namely [Cu4I4(bib)2]n·n(DMF) (1, bib = 1,4-bis(imidazolyl)butane, DMF = N,N'-dimethylformamide), which was synthesized by the self-assemble reaction of CuI, bib and KI under solvothermal conditions. Remarkably, compound 1 shows promising photocatalytic performance toward to the degradation of MB solution under visible light irradiation. For the COPD treatment, the ELISA detection kit was conducted to determine the content of INF-γ released by the respiratory tract mucosal epithelial cells. In addition to this, the activation levels of the NF-κB signaling pathway were still need to be assessed by the real time RT-PCR after the compound treatment.

Highlights

Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases, which is the fourth leading cause of death in the world, and it is expected to rise to the third place in 2025, becoming the fifth major disabling disease in the world, seriously threatening human health [1]
A shown in Fig. 1, four I− anions as μ3-bridges link four Cu(I) ions to forming a [Cu4I4] cubane subunit with the Cu...Cu distances ranging from 2.6620(19) to 2.8366(9) Å, and all of the Cu(I) ions are tetrahedrally coordinated by three μ3-I− anions and one nitrogen atom of bib ligand
We have proved that the compound could significantly reduce the content of INFγ released by the respiratory tract mucosal epithelial cells

Summary

Introduction

Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases, which is the fourth leading cause of death in the world, and it is expected to rise to the third place in 2025, becoming the fifth major disabling disease in the world, seriously threatening human health [1]. ELISA detection kit ELISA detection was conducted in this present experiment to determine the content of INF-γ released by the respiratory tract mucosal epithelial cells after indicated treatment. This preformation was finished totally under the guidance of the instructions with only a little change. The respiratory secretions was collected ang the content of the INF-γ released by the respiratory tract mucosal epithelial cells was determined with indicated ELISA detection kit. After COPD animal model construction and indicated compound treatment, the real time RT-PCR was carried out to determine the activation of the NF-κB signaling pathway in the respiratory tract mucosal epithelial cells.

Results And Discussion

Conclusions

Ethics approval

Code availability