Abstract
In the present study, a superfusion method was used to investigate the α 2-adrenoceptor mediated modulation of the electrically evoked release of radiolabeled noradrenaline in vas deferens and cerebral cortex slices of streptozotocin-diabetic and control rats 8–10 weeks after the induction of diabetes. Stimulation of α 2-adrenoceptors led to a significantly smaller inhibition of radiolabeled noradrenaline release in the vas deferens of diabetic rats as compared to control rats. In the cerebral cortex no such difference was detected. It is concluded that these effects could be due to a decrease in the number of presynaptic α 2-adrenoceptors in the vas deferens of diabetic rats. The results of this study show that the superfusion technique offers a simple possibility to obtain information about the functional integrity of noradrenergic neurons in the peripheral nervous system and central nervous system in diabetes mellitus. Moreover, the results provide an indication for a different time scale in the development of neuropathy in the peripheral and central nervous system of streptozotocin-diabetic rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
