Abstract
We succeeded in size-dependent continuous filtration of microparticles using magnetically driven microtool (MMT) and centrifugal foce in a microfluidic chip. Novelties of this paper are summarized as follows. (1) Filtering efficiency was improved than filtration by solely centrifugal force by MMT rotation. (2) This filtration is robust against pressure fluctuation in a chip by mechanical particle separation using sidewalls. (3) Size-classified microparticles can be trapped in the microchannels and treated by reagent. Microparticles having different sizes flow in spiral microchannels and separated according to their sizes by the graduated gaps between sidewall and bottom by centrifugal force. MMT is positioned inside the microchamber and rotated by external magnetic force. Rotation of MMT enhances the sorting efficiency. By flow control, size-classified microparticles can also be aligned in the circular microchannel and retrieved concurrently. We demonstrated filtration of the microparticles using 3D-MMT rotation and centrifugal force and trap of the size-classified microparticles in a chip.
Published Version
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