Abstract
HBO2 can produce relief of acute pain in mice.1 We have previously reported that the acute antinociceptive effect of HBO2 was reduced by intracerebroventricular (i.c.v.) administration of the alpha2 adrenergic antagonist yohimbine in saline solution.2 However, there were concerns that saline might disturb the ion balance of the cerebrospinal fluid (CSF) and alter the effect of HBO2.3 The aim of this study was to ascertain the effect of yohimbine prepared in artificial CSF (aCSF) on HBO2-induced antinociception.
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