286 LONG TERM PROGRESSION-FREE, OVERALL AND CANCER-SPECIFIC SURVIVAL IN SPORADIC, FAMILIAL AND HEREDITARY PROSTATE CANCER PATIENTS IN GERMANY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized I1 Apr 2010286 LONG TERM PROGRESSION-FREE, OVERALL AND CANCER-SPECIFIC SURVIVAL IN SPORADIC, FAMILIAL AND HEREDITARY PROSTATE CANCER PATIENTS IN GERMANY Kathleen Herkommer, Christoph Winkler, Juergen Gschwend, and Martina Kron Kathleen HerkommerKathleen Herkommer München, Germany More articles by this author , Christoph WinklerChristoph Winkler München, Germany More articles by this author , Juergen GschwendJuergen Gschwend München, Germany More articles by this author , and Martina KronMartina Kron Ulm, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.348AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is consent that a positive family history of prostate cancer is one of the greatest risk factors for prostate cancer. But there are conflicting reports regarding the effect of family history on prognosis of prostate cancer patients. The aim of this study was to determine the impact of a positive family history on survival of prostate cancer patients after radical prostatectomy in Germany. METHODS In the national research program ¡°Familial prostate cancer in Germany ± data on follow-up and family history of prostate cancer patients in Germany has been collected since 1993. 10.349 prostate cancer patients who underwent radical prostatectomy were classified as sporadic (SPC), familial (FPC) and hereditary (HPC) cases. Patients were classified as having sporadic prostate cancer if they didn't have any first degree relatives with prostate cancer. Hereditary prostate cancer was defined as families with either prostate cancer diagnosed in at least three generations, at least three first degree relatives with prostate cancer or at least two cases diagnosed before the age of 55. Patients with familial prostate cancer had at least one first degree relative with prostate cancer but didn't meet the criteria for hereditary cancer. Progression free survival (PFS), overall survival (OS) and cancer specific survival (CSS) after radical prostatectomy in SPC, FPC and HPC cases was analysed according to the method of Kaplan and Meier defining progression as a Serum-PSA of ¡Ý0,2 ng/ml. Survival rates were compared with the log rank test. RESULTS We found 872 (8,4%) HPC cases, 2.509 (24,2%) FPC cases and 6.968 (67%) SPC cases. The 10-year PFS rate was 49% (95% KI: 47% “C 54%) in the SPC group, 46% (95%-KI: 43% “C 49%) in the FPC group and 45% (95%-KI: 40% “C 49%) in the HPC group. The 10-year OS rate was 86% (95% KI: 84% “C 88%), 84% (95% KI: 81% “C 86%) and 80% (95% KI: 75% “C 83%) in SPC, FPC and HPC cases. The 10-year CSS rate was 93% (95% KI: 91% “C 94%) in the SPC group, 91% (95% KI: 88% “C 93%) in the FPC group and 87% (95% KI: 83% “C 90%) in the HPC group. Survival of SPC, FPC and HPC cases was remarkably different (p=0,007 for PFS, p<0,001 for OS, p<0,001 for CSS). CONCLUSIONS In our follow-up analysis of 10.349 prostate cancer patients after radical prostatectomy in Germany, long-term PFS, OS and CSS of patients with a positive family history of prostate cancer was different to those without a family history. Our findings suggest that hereditary prostate cancer may have a slightly more aggressive course than sporadic prostate cancer. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e113 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kathleen Herkommer München, Germany More articles by this author Christoph Winkler München, Germany More articles by this author Juergen Gschwend München, Germany More articles by this author Martina Kron Ulm, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...