Abstract
Congenital disorders, cancer, trauma, infection, inflammation, iatrogenic injuries, or other conditions of the bladder can lead to organ damage or complete loss of function. Most of these situations require eventual reconstructive procedures. These procedures can be performed with native non-urological tissues (skin, gastrointestinal segments, or mucosa), homologous tissues from a donor (cadaver or living donor kidney), heterologous tissues or substances (bovine collagen), or artificial materials (silicone, polyurethane, Teflon). However, these materials often lead to complications after reconstruction. The implanted tissue is sometimes rejected, and often the inherently different functional aspects of the different tissues or materials used in the reconstruction cause a mismatch in the system. As an example, current methods of replacing bladder tissue with gastrointestinal segments can be problematic due to the opposite ways in which these two tissues handle solutes – urological tissue normally excretes material, but gastrointestinal tissue generally absorbs the same materials, and such a mismatch can lead to metabolic complications as well as infection. The replacement of lost or deficient urological tissues with functionally equivalent ones would improve the outcome of reconstructive surgery for the bladder. This may soon be possible with novel tissue engineering techniques.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.