Abstract
This chapter discusses various ionic events relevant to neutrophil activation. A variety of ionic events are described in neutrophils in response to stimulation by physiological and nonphysiological agonists. Increased rates of the transport of sodium, potassium, calcium, and hydrogen, together with transient changes in the intracellular levels of these ions, are reported. Stimulated changes in the membrane potential of neutrophils are also described in this chapter. The measurement of the rates of transport of various ions in neutrophils, as in other cells, relies on the general principles of compartmental analysis. In view of the potential complexity of the behavior of multicompartment systems, the general outline of the latter is provided. In practice, the following parameters are measured: (1) the initial rate of uptake or influx, (2) the initial rate of efflux, in which case, the exit from the cells of a labeled ion with which the cells had previously been loaded can be monitored, and (3) steady-state measurements.
Published Version
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