Abstract
METHODS Cartilage Mapping. The trochlea, tibial plateaus and femoral condyles were harvested as cartilage-bone blocks from a cadaveric knee of a 47-year-old woman. These blocks were immersed in PBS and 5 different users performed 3 consecutive mappings on each cartilage surface with the Arthro-BSTTM. Biomechanical and Biochemical Analyses. Full thickness 4mm diameter cartilage disks with a thin bone layer were harvested from mapped cartilage surfaces. Stress relaxation testing was performed on cartilage disks in unconfined compression. The results were fitted to the fibril-reinforced biphasic model [1] to provide the equilibrium modulus the fibril modulus and the permeability Cartilage disks were also analyzed for the INTRODUCTION Pharmaceutical treatments are under development to prevent, delay or reverse progression of OA. However, no generally accepted clinical outcome measure to indicate cartilage health versus disease is currently available. Our objective is to provide an arthroscopic device, the Arthro-BSTTM, which measures cartilage streaming potentials in order to evaluate the efficacy of new treatments and to help surgeons to more precisely identify
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