Abstract
Abstract Introduction Fertility and birth control is a worldwide health concerning since it is an important issue regarding economic, religious, or social impacts for couples. Women have plenty options since oral hormonal anticonception were introduced in daily practice. However, men remain restricted to condoms or vasectomy surgery and until now 50% of natural conceptions are considered not desired. Many options have been proposed for oral contraception (hormonal or non-hormonal strategies) but still none of them seems to be safe about efficacy, side effects, or reversibility. Alpha-blockers have shown effects in ejaculation and is a matter of debate if those are from retrograde ejaculation or impaired sperm emission. Actual data suggest specific alfa-1A blockage effect may achieve azoospermia, however it is not clear when it occurs and the exact mechanism concerning ejaculation disorder. Objective The main objective of this study is to determine how semen analysis on sperm concentration is affected by oral tamsulosin 0,8mg in a 24-hour range after intake. Methods 34 health men between 18-45 years-old recruited after consent for semen analysis with inclusion criteria OMS normal parameters and ability to masturbation for collect samples. Exclusion criteria were hepatic disorders, neurological disorders, renal disorders, inability to collect sperm from masturbation, previous or concomitant use of testosterone or other anabolic steroids and previous or concomitant use of possible medications regarding interaction. 31 individuals met including criteria and were designated to oral intake for tamsulosin 0,8mg and collect sperm sample after 4, 8, 12, 16,20 and 24 hours in different moments to determine 6 semen analysis in different medication serum concentrations. Minimum interval with each intake and semen analysis were 1 week. In case of any participant achieve azoospermia, urine analysis was performed to determine if it was retrograde ejaculation. Samples were determined about volume and sperm concentration. Side effects were considered after each week. Protocol was approved at local ethical committee (CAAE: 26124719.2.0000.0082). Results Low volume and sperm concentration compared to basal was achieved in 29/31 (93,6%) while azoospermia was diagnosed in 25/31 (80,7%). Only 1 subject was identified as retrograde ejaculation with 24 men with absolute azoospermia. Intervals of azoospermia achievement varied from 8 to 16 hours after oral tamsulosin 0,8mg intake. Most of subjects returned normal semen parameters with 24 hours after intake medication. Side effects were most regarding ejaculation disorder and discomfort, minor subjects with headache or dizziness but not considered bothering or incapacitant. Conclusions Ejaculation disorder in men after oral tamsulosin intake correspond to impaired emission in most subjects in this study. This could be an option for further studies regarding male birth control without risks of impaired spermatogenesis as hormonal approach with safe reversibility and well tolerated side effects. Disclosure No
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