Abstract
Cannabidiol (CBD) has been implicated as beneficial in variety of skin conditions, including acne, atopic dermatitis, psoriasis, scleroderma, and pruritis. CBD mediates its effect through skin’s own endocannabinoid system composed of CB1 and CB2 receptors, but detailed mechanism of action in skin and clinical efficacy potential needs to be established. In this study we investigated the role of CBD on modulation of heat shock protein pathway in human dermal fibroblasts. Cells were treated with various concentration of CBD and amount of HSP-70 induced was evaluated by ELISA. In addition, clinical efficacy was assessed using an in vivo model. Erythema was induced by topical methyl nicotinate (MN), leading to prostaglandin release and vasodilatation of the peripheral blood capillaries of the skin. CBD was shown to significantly stimulate HSP70 protein level in human dermal fibroblast cells as well as reduce erythema in a clinical model of redness.
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