長跑運動對健康老年男性單核球分泌白血球間素-2和白血球間素-4的影響

Abstract

After aging, Human immune function undergoes adverse change. The immune system is dysregulated and potentially lead to an increased risk of infection, autoimmune disorder, and certain cancers disease in the elder, it is an adversely affect of human health. Taiwan is a country of aging now and the ratio of the elder is increasing. How to increase the function of immune and keep health of the elder is the main topic of science. Long distance running is a kind of exercise that can increase endurance. Whether the long distance running can promote the immune function of the elder or not is worth to investigate. Thus, the purpose of this study is to investigate the affect of regular long distance running on secretion of interleukin- 2, interleukin-4 and T lymphocyte’s proliferation from human mononuclear cell of healthy men. Thirty-three health male will be recruited as subjects, including ten sedentary young (SY) male, twelve sedentary elderly (SE) male and eleven long distance runners (LDR). After 2 weeks of maximal oxygen uptake measured, 150 cc of vein blood was taken, Secretion of IL-2, IL-4 from mononuclear cell and T lymphocyte proliferation was measured, one way ANOVA was used to compare the difference among the three groups. The results of this study were as followed: l) the secretion of IL-2 from monocyte of LDR (20.lug/ml) was significantly less than SY (22.2ug/ml) (P＜0.05), There was no significant difference between SE and LDR in the secretion of IL-2 from human monocyte. 2) The secretion of IL-4 from monocyte of LDR (17.69ug/ml) is significant higher than SY (16.31ug/ml) and SE (16. 14ug/ml) (P＜0.05), There was no significant difference between SY and SE in the secretion of IL-4 from human monocyte. 3) The proliferation of T Lymphocyte was no significant difference among SY,SE and LDR …… The result showed that the long distance running cannot significantly promote T lymphocyte’s function, but promote B lymphocyte’ regulative function.