Abstract
Chemical screening of a Formosan sea bamboo octocoral Isis hippuris have led to the isolation of nine spiroketal steroids, including a new metabolite, 24-dehydrohippuristanol (1), a new natural product, hippuristanol 11-one (2), as well as seven known analogs, hippuristanol (3), 22-epi-hippuristanol (4), hippurin-1 (5), 22-epi-hippurin-1 (6), 3-acetyl-22-epi-hippurin-1 (7), 3α-acetoxy-11β-hydroxy-24-methyl-22,25-epoxy-5α-furostan-18,20β-lactone (8) and (22S)-3α-acetoxy-11β,18α-dihydroxy-24-methyl-18,20β;22,25-diepoxy-5α-furostane (9). The structures of steroids 1–9 were corroborated by 2D NMR experiments and comparison with literature data. The configurations of steroids 3, 4, 6 and 9, obtained in previous studies, were reported for the first time in this study by single-crystal X-ray diffraction analysis. Steroid 1 exhibited cytotoxic effects against DLD-1 and LoVo cancer cells with IC50 values of 5.54 and 6.89 μM, respectively.
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