Abstract
Regularly administered combination-type oral contraceptives are the most effective contraceptives with good cycle control. The need for sustained motivation and the dropout rate of nearly 50% in India makes the present search for a depot hormonal preparation essential. Clinical data and discovered problems with 2 long-acting preparations are described. Tests were conducted with a 6-month subcutaneous implant (silastic or biodegradable) of Norethindrone acetate and with monthly injections of a combination of Norethisterone enanthate and estradiol valerate. Accidental pregnancy rates with both types of medication were high increasing toward the end of the period with the implant. Unpredictable irregular bleeding was the main reason for dissatisfaction with both medications. Low body weight was related to high side effect and pregnancy rates with the implant. It is concluded that depot preparations are still in a primitive stage of development. Work remains to be done on them.
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