Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common cutaneous malignant tumor, occurring frequently in the head and neck. The latest National Comprehensive Cancer Network (NCCN) Guidelines classify cSCC into low-, high-, and very-high-risk groups using multiple risk factors. There were no detailed and accurate prognostic models for the newly established “very-high-risk” group. We identified the following four important risk factors for local relapse, nodal relapse, and SCC-related death in a previous study: recurrent tumor, high-risk histologic features, >6-mm tumor thickness or invasion beyond the subcutaneous fat layer, and lymphatic or vascular involvement.
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