Abstract
A retrospective one year study of all inborn infants of ≥35 weeks' gestation was undertaken to determine neonatal effects of maternal Isoxsuprine (I) administration. Mothers of 43 infants received I. within 48 hours of delivery and mothers of 107 received no I. When divided into gestational age groups, there were no significant differences in infants' birthweights, Apgar scores, pulse rates, hematocrits, or the incidence of respiratory diseases. Hypocalcemia, hypoglycemia, abdominal symptoms of ileus, hypotension and death were all significantly higher in infants whose mothers received I. Hypotension and death occurred predominantly in very pre-term infants.Significant ileus and metabolic derangements appear to be related to maternal I. administration. The high mortality and incidence of hypotension deserves further investigation.
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