Abstract
TLR-4 signals via two distinct pathways, a MyD88-TIRAP pathway and a TRAM dependent pathway. Previous work in our laboratory has suggested a central role of TLR-4 in injury development in an in vivo model of lung ischemia reperfusion (IR). To further understand how TLR-4 activation translates to injury in lung IR, we sought to examine the functional requirements of the adapter proteins in alveolar macrophages using a primary cell culture model of hypoxia and reoxygenation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
