226 INCREASED INCIDENCE OF PATHOLOGICALLY NON-ORGAN CONFINED PROSTATE CANCER IN AFRICAN-AMERICAN MEN ELIGIBLE FOR ACTIVE SURVEILLANCE

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (I)1 Apr 2013226 INCREASED INCIDENCE OF PATHOLOGICALLY NON-ORGAN CONFINED PROSTATE CANCER IN AFRICAN-AMERICAN MEN ELIGIBLE FOR ACTIVE SURVEILLANCE Yun-Sok Ha, Amirali Salmasi, Jeong Hyun Kim, Jae Young Joung, Dong Hyeon Lee, Wun-Jae Kim, and Isaac Yi Kim Yun-Sok HaYun-Sok Ha New Brunswick, NJ More articles by this author , Amirali SalmasiAmirali Salmasi New Brunswick, NJ More articles by this author , Jeong Hyun KimJeong Hyun Kim Chuncheon, Korea, Republic of More articles by this author , Jae Young JoungJae Young Joung Goyang, Korea, Republic of More articles by this author , Dong Hyeon LeeDong Hyeon Lee Seoul, Korea, Republic of More articles by this author , Wun-Jae KimWun-Jae Kim Cheongju, Korea, Republic of More articles by this author , and Isaac Yi KimIsaac Yi Kim New Brunswick, NJ More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1606AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES African-American (AA) men have a relatively higher risk of developing prostate cancer (PCa) and dying of PCa compared to White-American (WA) men. For this reason, it is unclear whether the same active surveillance (AS) criteria should be applied to AA men. The aim of the present study is to compare the clinicopathologic findings of AA and WA men with prostate cancer who were candidates for active surveillance (AS) and underwent radical prostatectomy (RP). METHODS Prospectively maintained database of men who underwent RP from two academic centers were analyzed retrospectively. Post-operative pathologic characteristics of patients who met the AS inclusion criteria of the University of California, San Francisco (UCSF) and National Comprehensive Cancer Network (NCCN) were evaluated. After RP, the rate of pathological upstaging and Gleason upgrading were compared between AA and WA. RESULTS In the AA cohort, 196 and 124 met the UCSF and NCCN criteria for AS, respectively. With respect to WA patients, 191 and 148 fulfilled the AS criteria for UCSF and NCCN. AA men had higher percentage of maximum biopsy core than WA (15.3- 20.4% vs. 11.5-15.0%, P< 0.05, respectively) in both cohorts. In addition, a greater proportion of AA men had multiple positive biopsy cores compared to WA (45.2% vs. 33.1%, P= 0.046) under NCCN criteria. A higher proportion of AA men were upstaged compared to WA (19.4% vs. 10.1%, P= 0.037). A multivariate regression test revealed that age, preoperative PSA, and number of positive cores were independent predictors of more advanced disease (upstaging and/or upgrading) in AA men. CONCLUSIONS AA men who were candidates for AS criteria had worse clinicopathological features on final surgical pathology than WA men. These results suggest that a more stringent AS criteria should be considered in AA men with prostate cancer. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e93 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yun-Sok Ha New Brunswick, NJ More articles by this author Amirali Salmasi New Brunswick, NJ More articles by this author Jeong Hyun Kim Chuncheon, Korea, Republic of More articles by this author Jae Young Joung Goyang, Korea, Republic of More articles by this author Dong Hyeon Lee Seoul, Korea, Republic of More articles by this author Wun-Jae Kim Cheongju, Korea, Republic of More articles by this author Isaac Yi Kim New Brunswick, NJ More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...