Abstract

Disruptions in the balance of excitation-inhibition (E/I) ratios are implicated as a common pathway in Autism Spectrum Disorder (ASD). This implication may have important consequences for treatment developments as several existing agents can shift E/I balance. Bumetanide is an E/I-shifting candidate due to its putative actions on chloride homeostasis and GABAergic transmission. In this part of the symposium, we present effects of bumetanide on cognitive measures as part of the forthcoming results of the BAMBI trial.

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