Abstract
Electrically stimulated osteogenesis by implanted cathodes is known to occur with a variety of electrode conditions and materials and is being used clinically world-wide. In an attempt to study the mechanism(s), mouse bone marrow cells were exposed to several metal cathodes in vitro. Specific population shifts were seen, among them a decrease in neutrophils and an increase in eosinophils, especially with platinum. Fibroblast cultures, exposed to the same cathodes, showed little damage or change. The current-potential behavior was measured for a number of implantable metals and alloys in a biological medium. The conditions reported to induce osteogenesis fell into a wide, but defined region over which the reduction of oxygen occurs. The relationship of this and other faradaic reactions to electrical osteogenesis needs further elaboration.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
